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Similarly, no significant changes in LINE-1 and Alu methylation among female nurses was observed, although several gene-specific hypomethylation effects to the estrogen receptor gene ESR1 (associated with heightened estrogen sensitivity), to the tumor suppressor genes TP53 and BRCA1 (indicating possible disruption in cell cycle regulation and DNA repair mechanisms) were reported

The level of NAD + decreases with aging and the cumulative effects of oxidative stress ratios of NADP + and NADPH gradually shifts to higher NADP + relative to NADPH

F., Almeida, M

4.2 Neurodegenerative diseases The WHO (World Health Organization) has reported one billion neurological cases globally [59]